From the Tools menu, choose Options... In the Options Information Box, complete the following:

Getting Started

Real Name: Your Name
Return Address: Your email address
Mail Server (Incoming): yoursite.com
Login Name: Email Username
SMTP Server (Outgoing): yoursite.com
Allow Authentication: Check

Checking Mail

Save Password: Check

Incoming Mail

Leaving Copy on Server: Check (if desired)

Sending Mail

Return Address: Return Address
Allow Authentication: Check

Congratulations, you've now setup Eudora 5 to use your email account. Repeat the above steps to setup further email accounts.